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4. Compatible with Demise in aged or sick folks or in existence of obstructed airway, other harmful agents, or publicity to chilly.pentobarbital will decrease the level or effect of fentanyl intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Coadministration of fentanyl with CYP3A4 inducers